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*Testing conducted by otto labs in May 2024 using otto-SR on the bench-SR benchmark.
otto-SR greatly increases the relevance and impact of systematic reviews. otto-SR reproduced 12 reviews from the April 2024 Cochrane issue, uncovered new studies, and altered their conclusions.
increase in relevant studies compared to human screening
studies gained statistical significance
study lost statistical significance
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On average, the 12 reviews published in the April 2024 Cochrane issue each included 5 human-screened papers (64 in total) in their meta-analyses. With otto-SR, we found that each review could have included, on average, 4 additional papers (54 total)—an 84% increase—while still adhering to each review’s protocols. These additions had a significant impact on the conclusion of each review.
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A Phase III trial to evaluate the effect of perioperative nutrition enriched with eicosapentaenoic acid on body weight loss after total gastrectomy for T2-T4a gastric cancer
2012 | Yoshikawa, T; Hiki, N; Taguri, M; Sano, T; Nunobe, S; Taniguchi, H; Fukushima, R; Cho, H; Morita, S; Tsuburaya, A
Modified enhanced recovery after surgery protocols are beneficial for postoperative recovery for patients undergoing emergency surgery for obstructive colorectal cancer: A propensity score matching analysis
2018 | Shang Y.; Guo C.; Zhang D.
An audit of nutritional practices in patients with oesophago-gastric malignancies undergoing surgical resection: A single centre cohort study
2015 | Bidgood E.
A minor but deadly surgery of colonic polypectomy in an elderly and fragile patient: A case report and the review of literature
2016 | Yuan X.; Zhou G.; He Y.; Feng A.
Impact of perioperative enteral immunonutrition in patients with gastrointestinal cancer undergoing elective surgery: a randomized controlled trial
2021 | Yu, J; Xiao, G; Zhou, Y; Ye, Y; Wang, B
A Double-Blinded Randomized Clinical Study on the Therapeutic Effect of Gastrografin in Prolonged Postoperative Ileus After Elective Colorectal Surgery
2016 | Biondo, S; Miquel, J; Espin-Basany, E; Sanchez, JL; Golda, T; Ferrer-Artola, AM; Codina-Cazador, A; Frago, R; Kreisler, E
The clinical value and usage of inflammatory and nutritional markers in survival prediction for gastric cancer patients with neoadjuvant chemotherapy and D2 lymphadenectomy
2020 | Li Z.; Li S.; Ying X.; Zhang L.; Shan F.; Jia Y.; Ji J.
Endoscopic Vacuum Therapy (EVT)-a New Concept for Complication Management in Bariatric Surgery
2017 | Schmidt F.; Mennigen R.; Vowinkel T.; Neumann P.A.; Senninger N.; Palmes D.; Laukoetter M.G.
Effects of preoperative and postoperative enteral nutrition on postoperative nutritional status and immune function of gastric cancer patients
2015 | Ding, D; Feng, Y; Song, B; Gao, S; Zhao, J
Operative Management of Crohn's Disease of the Colon Including Anorectal Disease
2007 | Steele S.R.
Case reports of obese endometrial cancer patients with levonorgestrel IUS to reduce the risk of laparoscopic surgery
2023 | Roze I.; Kohei N.; Yumi T.; Tomoko U.; Momoko Y.; Shinichiro S.; Kazuya T.; Kayo I.; Hiroshi T.; Hiroaki S.
Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma
1994 | Fan, ST; Lo, CM; Lai, EC; Chu, KM; Liu, CL; Wong, J
Impact of malnutrition on gastrointestinal surgical patients
2016 | Mosquera C.; Koutlas N.J.; Edwards K.C.; Strickland A.; Vohra N.A.; Zervos E.E.; Fitzgerald T.L.
Protein S deficiency with a PROS1 gene mutation in a patient presenting with mesenteric venous thrombosis following total colectomy
2011 | Ji M.; Yoon S.N.; Lee W.; Jang S.; Park S.H.; Kim D.-Y.; Chun S.; Min W.-K.
Preoperative serum C-reactive protein concentration can be used to detect gallbladder rupture in dogs with gallbladder mucocele
2022 | Asakawa M.; Fukuzawa M.; Asakawa M.G.; Flanders J.A.
High dose N-acetylcysteine to prevent pulmonary complications in partial or total transthoracic esophagectomy: Results of a prospective observational study
2007 | Zingg U.; Hofer C.K.; Seifert B.; Metzger U.; Zollinger A.
111 ERAS colorectal resections for cancer with a median stay of 5 days. The era of fast track colorectal cancer surgery
2011 | Abraham N.
The future of antihypertensive treatment.
2007-03 | Israili ZH; Hernández-Hernández R; Valasco M
Effects of a whey peptide-based enteral formula diet on liver dysfunction following living donor liver transplantation
2014 | Arakawa Y.; Shimada M.; Utsunomiya T.; Imura S.; Morine Y.; Ikemoto T.; Hanaoka J.
Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon device
2019 | Casella-Mariolo J.; Castagneto-Gissey L.; Angelini G.; Zoli A.; Marini P.; Bornstein S.R.; Pournaras D.J.; Rubino F.; le Roux C.W.; Mingrone G.; Casella G.
The effect of preoperative carbohydrate loading on hormonal changes, hepatic glycogen, and glucoregulatory enzymes during abdominal surgery
1996 | Thorell A.; Alston-Smith J.; Ljungqvist O.
[Duodenum preserving resection of the head of the pancrease in therapy of pancreas divisum].
1997 | Widmaier, U; Schmidt, A; Schlosser, W; Beger, H G
Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia
2012 | Shneider, BL; Magee, JC; Bezerra, JA; Haber, B; Karpen, SJ; Raghunathan, T; Rosenthal, P; Schwarz, K; Suchy, FJ; Kerkar, N; et al.
Etoricoxib in Acute Soft Tissue Rheumatism Affecting the Shoulder
2009 | NCT00876317,
Hellenic association for the study of the liver clinical practice guidelines: Autoimmune hepatitis
2019 | Dalekos G.N.; Koskinas J.; Papatheodoridis G.V.
Mechanical small bowel obstruction due to appendiceal tourniquet: A case report and review of literature
2019 | Ahmed K.A.; Hamdy A.M.F.; Seifeldin M.I.; Elkeleny M.R.
Implementation of postoperative nutritional support for gastric cancer patients in China
2015 | Zhu B.; Gong K.; Peng J.; Du D.; Lian D.; Amin B.; Zhang N.
Preoperative body composition is influenced by the stage of operable pancreatic adenocarcinoma but does not predict survival after Whipple's procedure
2010 | Aslani A.; Gill A.J.; Roach P.J.; Allen B.J.; Smith R.C.
Preoperative carbohydrate loading with individualized supplemental insulin in diabetic patients undergoing gastrointestinal surgery: A randomized trial
2022 | Li X.; Liu L.; Liang X.-Q.; Li Y.-T.; Wang D.-X.
Is enhanced recovery protocol for gastric cancer feasible and safe in the west? A single center experience
2019 | Weindelmayer J.; Mengardo V.; Gasparini A.; Torroni L.; Benedetti B.; De Pasqual C.A.; Verlato G.; de Manzoni G.
Resolved: psychosocial interventions can improve clinical outcomes in organic disease (pro).
2002-07 | Williams, Redford B.; Schneiderman, Neil
Effects of multiple factorial intervention on ambulatory BP profile and renal function in hypertensive type 2 diabetic patients with overt nephropathy - a pilot study
2011 | Kanaoka, T; Tamura, K; Moriya, T; Tanaka, K; Konno, Y; Kondoh, S; Toyoda, M; Umezono, T; Fujikawa, T; Ohsawa, M; et al.
Associations of Biomarkers of Tubular Injury and Inflammation with Biopsy Features in Type 1 Diabetes
2024 | Limonte, CP; Prince, DK; Hoofnagle, AN; Galecki, A; Hirsch, IB; Tian, F; Waikar, SS; Looker, HC; Nelson, RG; Doria, A; et al.
Results of Laparoscopic Gastric Bypass in Patients with Cirrhosis
2004 | Dallal R.M.; Mattar S.G.; Lord J.L.; Watson A.R.; Cottam D.R.; Eid G.M.; Hamad G.; Rabinovitz M.; Schauer P.R.
Probiotics and synbiotics reduce infective complications from colorectal surgery
2022 | Kinross J.
A case of giant protein-losing gastric cancer treated by partial resection of the stomach
2005 | Nomura M.; Inoue Y.; Fujita S.; Sakao J.; Hirota M.; Souda S.; Ohshima M.
The Impact of Preoperative Enteral Nutrition Enriched with Eicosapentaenoic Acid on Postoperative Hypercytokinemia after Pancreatoduodenectomy: the Results of a Double-Blinded Randomized Controlled Trial
2019 | Ashida, R; Okamura, Y; Wakabayashi-Nakao, K; Mizuno, T; Aoki, S; Uesaka, K
The evaluation of the association between preoperative sarcopenia and postoperative pneumonia and factors for preoperative sarcopenia in patients undergoing thoracoscopic-laparoscopic esophagectomy for esophageal cancer
2023 | Fukushima T.; Watanabe N.; Okita Y.; Yokota S.; Matsuoka A.; Kojima K.; Kurita D.; Ishiyama K.; Oguma J.; Kawai A.; Daiko H.
Enteral Nutrition by Endoscopic Means; II. Complications and Management.
2004 | Hoepffner, N; Schroder, O; Stein, J
The effect of recombinant growth hormone on nitrogen balance in malnourished patients after major abdominal surgery
1995 | Wong, WK; Soo, KC; Nambiar, R; Tan, YS; Yo, SL; Tan, IK
Clinical Significance of Prognostic Nutrition Index in Patients with Crohn's Disease after Primary Bowel Resection
2024 | Bae H.W.; Lee Y.J.; Park M.Y.; Yang S.Y.; Han Y.D.; Cho M.S.; Hur H.; Lee K.Y.; Cheon J.H.; Carmichael J.C.; Min B.S.
Lactose after Roux-en-Y gastric bypass for morbid obesity, is it a problem?
2020 | Westerink F.; Beijderwellen H.; Huibregtse I.L.; De Hoog M.L.A.; De Brauw L.M.; Brandjes D.P.M.; Gerdes V.E.A.
Mid-term effects of sleeve gastrectomy on calcium metabolism parameters, vitamin D and parathormone (PTH) in morbid obese women.
2012 | Ruiz-Tovar, Jaime; Oller, Inmaculada; Tomas, Andres; Llavero, Carolina; Arroyo, Antonio; Calero, Alicia; Martinez-Blasco, Amparo; Calpena, Rafael
Key Articles and Guidelines for the Prevention of Venous Thromboembolism
2009 | Dobesh P.P.; Wittkowsky A.K.; Stacy Z.; Dager W.E.; Haines S.T.; Lopez L.M.; Nutescu E.; Phillips K.W.; Trujillo T.C.; Vondracek T.
Safety and Efficacy of CT-Guided Central Venous Catheter Gastric Insufflation in Percutaneous Gastrostomy
2022 | Zhang W.; Deng R.; Chen B.; Lv J.; Zhu T.; Huang M.; Xu G.; Liu F.; Zhang T.; Wang L.; Yue J.; Mu L.; Zhang C.
Secondary hyperparathyroidism following biliopancreatic diversion
1996 | Chapin B.L.; LeMar Jr. H.J.; Knodel D.H.; Carter P.L.
Revision of Roux-en-Y gastric bypass to distal bypass for failed weight loss
2011 | Rawlins M.L.; Teel II D.; Hedgcorth K.; Maguire J.P.
Class III obesity and its relationship with the nutritional status of vitamin A in pre- and postoperative gastric bypass.
2009 | Pereira, Silvia; Saboya, Carlos; Chaves, Gabriela; Ramalho, Andrea
Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling.
2010-02-19 | Hsiao, Ing-Tsung; Lin, Kun-Ju; Chang, Shi-Ing; Yen, Tzu-Chen; Chen, Tse-Ching; Yeh, Ta-Sen
Vitamin D levels in infants with biliary atresia: Pre- and post-kasai portoenterostomy
2016 | Ng J.; Paul A.; Wright N.; Hadzic N.; Davenport M.
Establishment and application of a new 4/6 infarct nephrectomy rat model for moderate chronic kidney disease
2024 | Sugai K.; Hirano M.; Oda A.; Fujisawa M.; Shono S.; Ishioka K.; Tamura T.; Katsumata Y.; Sano M.; Kobayashi E.; Hakamata Y.
Parenteral arginine infusion in humans: nutrient substrate or pharmacologic agent?
1992 | Sigal, RK; Shou, J; Daly, JM
Are vitamin B12 and folate deficiency clinically important after roux-en-Y gastric bypass?.
1998 | Brolin, R E; Gorman, J H; Gorman, R C; Petschenik, A J; Bradley, L J; Kenler, H A; Cody, R P
Survival impact of perioperative changes in prognostic nutritional index levels after esophagectomy
2022 | Haneda R.; Hiramatsu Y.; Kawata S.; Honke J.; Soneda W.; Matsumoto T.; Morita Y.; Kikuchi H.; Kamiya K.; Takeuchi H.
Mineral malnutrition following bariatric surgery
2013 | Gletsu-Miller N.; Wright B.N.
Role-play versus lecture methods in community health volunteers
2019 | Vizeshfar, F; Zare, M; Keshtkaran, Z
Comparison of clinical efficacy between standard sequential early enteral nutrition plus parenteral nutrition and parenteral nutrition support in patients undergoing gastrointestinal surgery: a clinical randomized controlled trial
2011 | Kang, W-M; Yu, J-C; Ma, Z-Q; Wang, J; Ge, J-N; Li, Z-T
Comparison of Clinical Outcomes and Postoperative Nutritional Status Between Early and Late Oral Feeding After Esophagectomy: an Open Labeled Randomized Controlled Trial
2025 | Na, KJ; Kang, CH; Kim, YR; Kang, MJ; Song, EH; Jang, EJ; Park, S; Lee, HJ; Park, IK; Kim, YT
A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series
2024 | Nemkov T.; Cendali F.; Dzieciatkowska M.; Stephenson D.; Hansen K.C.; Jankowski C.M.; D'Alessandro A.; Marker R.J.
Effect of Preoperative Malnutrition Based on Albumin and BMI on Hepatocellular Carcinoma Surgery and Prediction of Risk Factors of Complications.
2024-01-02 | Jin, Weiqiang; Jiang, Shiming; Chen, Anke; Chen, Yong
Nomogram to Predict Postoperative Intra-abdominal Septic Complications After Bowel Resection and Primary Anastomosis for Crohn's Disease
2020 | Zhu F.; Li Y.; Guo Z.; Cao L.; Feng D.; Zhang T.; Zhu W.; Gong J.
Early postoperative jejunostomy feeding with an immune modulating diet in patients undergoing resectional surgery for upper gastrointestinal cancer: a prospective, randomized, controlled, double-blind study
2006 | Lobo, DN; Williams, RN; Welch, NT; Aloysius, MM; Nunes, QM; Padmanabhan, J; Crowe, JR; Iftikhar, SY; Parsons, SL; Neal, KR; et al.
Effect of preoperative carbohydrate intake on gastric residual volume and pH in gynecologic laparoscopic surgery: A randomized controlled trial
2025 | Van Loi D.; Lam N.D.; Tuoi T.T.; Vinh T.V.T.
Perioperative Parenteral Nutrition in Adults with Inflammatory Bowel Disease: A Review of the Literature
2016 | Schwartz E.
Comparison between surgical outcomes of colorectal cancer in younger and elderly patients.
2011 | Jin, Longxue; Inoue, Norio; Sato, Naoki; Matsumoto, Susumu; Kanno, Hitoshi; Hashimoto, Yuko; Tasaki, Kazuhiro; Sato, Kinya; Sato, Shun; Kaneko, Katsutoshi
Randomized clinical trial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients
2004 | de Luis, DA; Izaola, O; Cuellar, L; Terroba, MC; Aller, R
Association between ERAS protocol and major postoperative complications and reasons for non-compliance in patients with esophageal cancer
2025 | Geroin C.; Weindelmayer J.; Camozzi S.; Leone B.; Turolo C.; Bencivenga M.; Sacco M.; De Pasqual C.A.; Vedovi E.; Priolo S.; Giacopuzzi S.
Prevalence of sarcopenia in patients with morbid obesity complicated by type 2 diabetes mellitus
2022 | Khitaryan A.; Abovyan A.; Mezhunts V.; Sarkisyan V.; Melnikov A.
New-Onset Proteinuria in a Patient With Schwannoma
2021 | Abu Salman L.; Kallis C.; Palmer M.; Bahrainwala J.; Geara A.S.
Effects of individualized parenteral nutrition designed by pharmacists on the recovery of postoperative gastric cancer patients
2022 | Fan Y.; Chen L.; Yu N.; Zhou Y.; Ma L.; Chen J.
Efficacy of perioperative immunonutrition in esophageal cancer patients undergoing esophagectomy
2019 | Kanekiyo, S; Takeda, S; Iida, M; Nishiyama, M; Kitahara, M; Shindo, Y; Tokumitsu, Y; Tomochika, S; Tsunedomi, R; Suzuki, N; et al.
Importance of "muscle" and "intestine" training before major HPB surgery: A review
2021 | Yokoyama Y.; Nagino M.; Ebata T.
The impact of early enteral feed composition on the rate of chyle leak post-oesophagectomy
2023 | Pan S.; Bushra R.; Cheah L.; Ribbits A.; Grimes S.; O'Neill J.R.
Longitudinal analysis of nutritional risk, muscle function and quality of life of patients with endstage liver disease waiting for liver transplantation
2023 | Trigui A.; Huard G.; Maxwell J.; Tremblay M.; Rose C.F.; Bemeur C.
Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial
2015 | Liu, Z; Li, C; Huang, M; Tong, C; Zhang, X; Wang, L; Peng, H; Lan, P; Zhang, P; Huang, N; et al.
Prospective study for the effects of pancreatic enzyme supplement therapy on quality of life and nutritional assessment after pancreatectomy
2013 | Park J.W.; Jang J.Y.; Hwang D.W.; Kim E.J.; Kang M.J.; Kwon W.; Chang Y.R.; Han I.W.; Kim S.W.
Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation--a randomized, double-blind trial
2005 | Rayes, N; Seehofer, D; Theruvath, T; Schiller, RA; Langrehr, JM; Jonas, S; Bengmark, S; Neuhaus, P
Outcomes following liver transplantation in young infants
2018 | Jain A.; Anand R.; Lerrett S.; Yanni G.S.; Mohammad S.; Doyle M.M.B.; Telega G.W.; Horslen S.P.
Percutaneous endoscopic gastrostomy with and without jejunal extension in patients with amyotrophic lateral sclerosis
2018 | Kirstein M.M.; Korner S.; Schneider A.; Manns M.P.; Petri S.; Voigtlander T.
Can early postoperative parenteral nutrition have some impact on postoperative inflammatory response intensity?
2021 | Kaška, M; Havel, E; Javorská, L; Matoušová, K; Páral, J; Chobola, M; Šafránek, P; Bezouška, J; Krčmová, LK
Neurological complications in pediatric liver transplant recipients: An analysis of risk factors and outcomes
2021 | Menon J.; Hakeem A.; Shanmugam N.; Thambidurai R.; Reddy M.S.; Rela M.
Enteral nutrition enriched with eicosapentaenoic acid (EPA) preserves lean body mass following esophageal cancer surgery: results of a double-blinded randomized controlled trial
2009 | Ryan, AM; Reynolds, JV; Healy, L; Byrne, M; Moore, J; Brannelly, N; McHugh, A; McCormack, D; Flood, P
Localised abdominal compartment syndrome: Bladder-over-gastric pressure ratio (B/G ratio) as a clue to diagnosis
2010 | Malbrain M.L.N.G.; De Laet I.E.; Willems A.; Van Regenmortel N.; Schoonheydt K.; Dits H.
Predictive factors of endocrine and exocrine insufficiency after resection of a benign tumour of the pancreas
2018 | Neophytou H.; Wangermez M.; Gand E.; Carretier M.; Danion J.; Richer J.-P.
Multivisceral transplantation for abdominal tumors in children: A single center experience and review of the literature
2017 | Lee E.; Hodgkinson N.; Fawaz R.; Vakili K.; Kim H.B.
Introduction to the special issue on gastroenterology
2019 | Coulter J.B.S.
Abnormal fatty acid metabolism in spinal muscular atrophy may predispose to perioperative risks
2012 | Zolkipli Z.; Sherlock M.; Biggar W.D.; Taylor G.; Hutchison J.S.; Peliowski A.; Alman B.A.; Ling S.C.; Tein I.
Nutritional status and feeding practices in gastrointestinal surgery patients at Bach Mai Hospital, Hanoi, Vietnam
2016 | Young L.S.; Huong P.T.; Lam N.T.; Thu N.N.; Van H.T.; Hanh N.L.; Tuyen leD.; Lien D.T.; Hoc T.H.; Tuyet C.T.; Anh N.Q.; Henry E.G.; Lenders C.M.; Gura K.M.; Bigornia S.J.; Apovian C.M.; Ziegler T.R.
Clinical Impact of Neoadjuvant Therapy on Nutritional Status in Pancreatic Cancer
2018 | Tashiro M.; Yamada S.; Sonohara F.; Takami H.; Suenaga M.; Hayashi M.; Niwa Y.; Tanaka C.; Kobayashi D.; Nakayama G.; Koike M.; Fujiwara M.; Fujii T.; Kodera Y.
Do directed cough maneuvers improve cough effectiveness in the early period after open heart surgery? Effect of thoracic support and maximal inspiration on cough peak expiratory flow, cough expiratory volume, and thoracic pain.
2008-08 | Fiore JF Jr.; Chiavegato LD; Denehy L; Paisani DM; Faresin SM
Role of specific nutritional biomarkers in predicting post-operative complications among patients undergoing elective abdominal surgery
2023 | Raghuraman H.; Gurushankari B.; Laya G.B.; Elamurugan T.; Shankar G.; Nanda N.; Thulasingam M.; Kate V.
Spanish survey on enhanced recovery after surgery.
2016-01-13 | Ripolles-Melchor, J; Casans-Frances, R; Abad-Gurumeta, A; Suarez-de-la-Rica, A; Ramirez-Rodriguez, J M; Lopez-Timoneda, F; Calvo-Vecino, J M
Total parenteral nutrition versus gastrostomy in the preoperative preparation of patients with carcinoma of the oesophagus
1981 | Lim, ST; Choa, RG; Lam, KH; Wong, J; Ong, GB
Early enteral nutrition and total parenteral nutrition on the nutritional status and blood glucose in patients with gastric cancer complicated with diabetes mellitus after radical gastrectomy
2018 | Wang, J; Zhao, J; Zhang, Y; Liu, C
Fat emulsion administration in the early postoperative period in patients undergoing esophagectomy for carcinoma depresses arachidonic acid metabolism in neutrophils
1999 | Sane, S; Baba, M; Kusano, C; Shirao, K; Kamada, T; Aikou, T
Hypertension in diabetes [1] (multiple letters)
2002 | Elegant V.
Carbohydrate-electrolyte (E-Lyte) solution enhances bowel preparation with oral fleet phospho-soda
2004 | Tjandra, JJ; Tagkalidis, P
Renutrition and perioperative immunonutritions in programed adult digestive surgery
2008 | Mabrut J.-Y.
Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients
2008 | Liang, B; Wang, S; Ye, YJ; Yang, XD; Wang, YL; Qu, J; Xie, QW; Yin, MJ
Enhanced muscle strength with carbohydrate supplement two hours before open cholecystectomy: a randomized, double-blind study
2016 | Gava, MG; Castro-Barcellos, HM; Caporossi, C; Aguilar-Nascimento, JE
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