Systematic reviews in hours,
not months.
otto-SR performs evidence synthesis from thousands of citations with better-than-human performance. Humans are in the loop at every step. Peer-reviewed in the Annals of Internal Medicine.
Trusted by researchers from leading institutions
Powering guideline groups
Peer-reviewed results
Better-than-human performance
otto-SR delivers state-of-the-art performance across abstract screening, full-text review, and data extraction, with peer-reviewed results benchmarked against both humans and competing systems.
between otto-SR, humans, and competitors
What researchers say
“Healthcare providers, policymakers, and others often must wait 6 to 12 months for systematic reviews, which is not helpful when timely decisions are needed. otto-SR is the answer. I'm so glad I found it — I use it for all my systematic reviews. otto-SR provides reliable, robust evidence quickly. It's intuitive, easy to use, and I believe it will soon become the standard for conducting systematic reviews.”
David Moher, PhD
Founder of PRISMA Guidelines
University of Ottawa
“Scoping reviews have exploded in popularity, but the volume of literature makes them increasingly difficult to do well. otto-SR is a promising tool for helping teams maintain comprehensiveness and methodological rigor while substantially reducing the time required to complete high-quality knowledge syntheses.”
Andrea Tricco, PhD
PRISMA-ScR Lead
Unity Health Toronto
“We were impressed with how otto-SR's platform streamlined the initial, quite time-consuming phase of this process. The system efficiently screened over 30,000 citations, saving our team many months of manual effort. Most importantly, the platform successfully surfaced a high number of relevant studies.”
Martin Juhl, PhD
Chief Scientific Officer
Cessatech
“otto-SR allowed us to complete in roughly two weeks what would normally take months, while maintaining methodological rigor. It captured all previously included studies and maintained high agreement with our human reviewers. It also identified additional eligible studies we had missed. It would be difficult to go back to the traditional fully manual approach after using it.”
Gregory Hundemer, MD, MPH
Clinician Scientist
University of Ottawa
“It would have taken our small team months to complete, even with very streamlined extraction steps. otto-SR completed extraction in under a week. Ultimately, it let me spend a lot more time on interpreting analyses, writing, and thinking through the more complex parts of the paper with evidence-informed results to guide it.”
Mairead Whelan, MPhil
Researcher
Oxford University
End-to-end system
Everything you need to write a systematic review
Simply give otto-SR your list of candidate papers and a simple PROSPERO-like protocol. otto-SR will take care of the entire systematic review process for you—from start to finish.
Find relevant papers
Search through the metadata of over 250 million research articles.
Integration with Retraction Watch flags retracted studies before they enter your review.
Screen titles, abstracts, and full-texts
otto-SR can screen thousands of studies in minutes, with better-than-human sensitivity.
Built-in multilingual support.
A Phase III trial to evaluate the effect of perioperative nutrition enriched with eicosapentaenoic acid on body weight loss after total gastrectomy for T2-T4a gastric cancer
Modified enhanced recovery after surgery protocols are beneficial for postoperative recovery for patients undergoing emergency surgery for obstructive colorectal cancer: A propensity score matching analysis
Impact of perioperative enteral immunonutrition in patients with gastrointestinal cancer undergoing elective surgery: a randomized controlled trial
A Double-Blinded Randomized Clinical Study on the Therapeutic Effect of Gastrografin in Prolonged Postoperative Ileus After Elective Colorectal Surgery
The clinical value and usage of inflammatory and nutritional markers in survival prediction for gastric cancer patients with neoadjuvant chemotherapy and D2 lymphadenectomy
Effects of preoperative and postoperative enteral nutrition on postoperative nutritional status and immune function of gastric cancer patients
Operative Management of Crohn's Disease of the Colon Including Anorectal Disease
Case reports of obese endometrial cancer patients with levonorgestrel IUS to reduce the risk of laparoscopic surgery
Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma
Impact of malnutrition on gastrointestinal surgical patients
A Phase III trial to evaluate the effect of perioperative nutrition enriched with eicosapentaenoic acid on body weight loss after total gastrectomy for T2-T4a gastric cancer
Modified enhanced recovery after surgery protocols are beneficial for postoperative recovery for patients undergoing emergency surgery for obstructive colorectal cancer: A propensity score matching analysis
Impact of perioperative enteral immunonutrition in patients with gastrointestinal cancer undergoing elective surgery: a randomized controlled trial
A Double-Blinded Randomized Clinical Study on the Therapeutic Effect of Gastrografin in Prolonged Postoperative Ileus After Elective Colorectal Surgery
The clinical value and usage of inflammatory and nutritional markers in survival prediction for gastric cancer patients with neoadjuvant chemotherapy and D2 lymphadenectomy
Effects of preoperative and postoperative enteral nutrition on postoperative nutritional status and immune function of gastric cancer patients
Operative Management of Crohn's Disease of the Colon Including Anorectal Disease
Case reports of obese endometrial cancer patients with levonorgestrel IUS to reduce the risk of laparoscopic surgery
Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma
Impact of malnutrition on gastrointestinal surgical patients
A Phase III trial to evaluate the effect of perioperative nutrition enriched with eicosapentaenoic acid on body weight loss after total gastrectomy for T2-T4a gastric cancer
Modified enhanced recovery after surgery protocols are beneficial for postoperative recovery for patients undergoing emergency surgery for obstructive colorectal cancer: A propensity score matching analysis
Impact of perioperative enteral immunonutrition in patients with gastrointestinal cancer undergoing elective surgery: a randomized controlled trial
A Double-Blinded Randomized Clinical Study on the Therapeutic Effect of Gastrografin in Prolonged Postoperative Ileus After Elective Colorectal Surgery
The clinical value and usage of inflammatory and nutritional markers in survival prediction for gastric cancer patients with neoadjuvant chemotherapy and D2 lymphadenectomy
Effects of preoperative and postoperative enteral nutrition on postoperative nutritional status and immune function of gastric cancer patients
Operative Management of Crohn's Disease of the Colon Including Anorectal Disease
Case reports of obese endometrial cancer patients with levonorgestrel IUS to reduce the risk of laparoscopic surgery
Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma
Impact of malnutrition on gastrointestinal surgical patients
Retrieve full-texts
Automatically get open-access full-texts. Easily bulk upload your own full-text PDFs. All stored privately and securely.
Extract data
Perform data extraction on hundreds of studies at once with verifiable citations direct from the full-text.
Extract hundreds of estimates from a single article, stratify papers by subgroups, pull data from supplementary materials, and automatically integrate information from clinical trial registries.
Risk of Bias assessment
Automatically assess risk of bias using validated tools like RoB 2, ROBINS-I, Newcastle-Ottawa, and QUADAS-2. otto-SR evaluates each domain with supporting justifications drawn directly from the full text.
Generate publication-ready traffic-light plots and summary figures instantly.
Automated study grouping
Multiple publications often report on the same study—counting them separately can bias your meta-analysis. otto-SR automatically detects and groups related publications using author overlap, trial registrations, and semantic similarity.
No more double-counting. No more missed links between papers.
Rapidly iterate and update
Change your protocol, refine your PICO, or update your database search. Re-screen and re-extract at the click of a button, instead of taking months of manual rework.
A new paradigm for truly ‘living’ reviews.
Clinical-Grade Results
Feel confident in your conclusions
Cochrane Reproduction Study
otto-SR greatly increases the relevance and impact of systematic reviews. When otto-SR reproduced 12 reviews from the April 2024 Cochrane issue, it uncovered new studies and altered their conclusions.
+78%
increase in relevant studies compared to human screening
2 / 12
studies gained statistical significance
1 / 12
studies lost statistical significance
8000+
hours saved for one review
Number of relevant studies included in the April 2024 Cochrane Issue
Security
Enterprise-grade security and controls
otto-SR meets the highest industry standards for security and compliance.
International standard for information security management systems.
Your data is never stored on or used to train AI models. All data can be purged on demand.